Transdermal Absorption of Methimazole- a Cat’s Tale

Transdermal application of methimazole in hyperthyroid cats: a long-term follow-up study.

Transdermal methimazole is suggested as an alternative to oral therapy for hyperthyroid cats that are difficult to pill. However, no information on long-term management with this treatment is available. Our objective was therefore to retrospectively evaluate the efficacy and safety of long-term transdermal methimazole treatment in hyperthyroid cats. Sixty cats with newly diagnosed hyperthyroidi...

Transdermal Absorption of Castor Oil

With the current high level of interest in patches to deliver drugs across the skin, the concept of external applications for delivery of medicinal substances is becoming widely accepted. This study evaluated the potential for transdermal absorption of castor oil, a treatment modality recommended by Edgar Cayce. Specific epoxydicarboxylic acids are known to be excreted via the urine when castor...

An Investigation into the CSF Absorption in Cats

Objective Cerebrospinal fluid (CSF), its secretion, circulation and absorption have been the subject of recent researches. There is a general agreement that the main site of CSF secretion is in the choroids plexus. However, the main absorption site is controversial. Some believe that arachnoid granulations are the principle sites of CSF absorption. In this study, different locations of CSF abs...

Digital Necrosis: A Hoarder’s Tale

In vitro human topical bioactive drug transdermal absorption: estradiol.

Use of the percutaneous route may avoid some of the undesirable side effects that occur following oral administration in estrogen replacement therapy. At present, knowledge of estradiol transdermal properties relating to delivery of drugs in the skin is lacking. One reason is that in the existing transport models of estradiol, the skin is regarded as a single layer. This study revealed a signif...